Terpenoids from the Octocoral Sinularia gaweli

International Journal of Molecular Sciences

Wun-Jie Lin²  Tung-Ying Wu⁶  Tzu-Rong Su⁴  Zhi-Hong Wen¹  Jih-Jung Chen⁷  Lee-Shing Fang⁵  Yang-Chang Wu⁶  Ping-Jyun Sung²  Vassilios Roussis³ 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mail:;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mail;Department of Beauty Science, Meiho University, Pingtung 912, Taiwan; E-Mail:;Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:;Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; E-Mail:;Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan; E-Mail:

关键词: Sinularia gaweli;    eudesmane;    cembrane;    octocoral;    iNOS;   

DOI  :  10.3390/ijms160819508

来源: mdpi

【 摘 要 】

Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2–4 are new isolates. The structures of new terpenoids 2–4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.