New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

Marine Drugs

Ting-Hsi Hsiao²  Chun-Sung Sung⁴  Yu-Hsuan Lan³  Yi-Chen Wang¹  Mei-Chin Lu²  Zhi-Hong Wen¹  Yang-Chang Wu³  Ping-Jyun Sung² 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan; E-Mail:

关键词: Nephthea columnaris;    cembrane;    octocoral;    antiinflammatory;    iNOS;    COX-2;    cytotoxicity;   

DOI  :  10.3390/md13063443

来源: mdpi

【 摘 要 】

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC₅₀ value of 9.80 μg/mL.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.