Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis

Marine Drugs

Li-Chung Hu⁵  Wei-Hsuan Yen⁵  Jui-Hsin Su⁵  Michael Yen-Nan Chiang⁷  Zhi-Hong Wen⁶  Wu-Fu Chen¹  Ting-Jang Lu⁴  Yu-Wei Chang⁸  Yung-Husan Chen³  Wei-Hsien Wang³  Yang-Chang Wu² 

[1] Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; E-Mail:;Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Department of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan; E-Mail:

关键词: cembrane;    norcembrane;    Sinularia flexibilis;    Sinularia gaweli;    X-ray;    anti-inflammatory activity;   

DOI  :  10.3390/md11062154

来源: mdpi

【 摘 要 】

A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.