Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

Molecules

Yu-Fang Lin¹  Chao-Ying Kuo²  Zhi-Hong Wen¹  Yen-You Lin¹  Wei-Hsien Wang¹  Jui-Hsin Su²  Jyh-Horng Sheu¹ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:

关键词: flexibilisquinone;    cultured soft coral;    Sinularia flexibilis;    anti-inflammatory;    iNOS;    COX-2;   

DOI  :  10.3390/molecules18078160

来源: mdpi

【 摘 要 】

A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinulariaflexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.