Artificial pneumothorax improves radiofrequency ablation of pulmonary metastases of hepatocellular carcinoma close to mediastinum

BMC Cancer

Wenli Lin¹  Taiyang Zuo²  Fengyong Liu²  Jinshun Xu³ 

[1] Department of Interventional Oncology, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, Shandong, China;Department of Interventional Oncology, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, Shandong, China;Department of Interventional Radiology, Department of Interventional Ultrasound, Chinese PLA General Hospital, 100853, Beijing, Shandong, China;Department of Interventional Oncology, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, Shandong, China;Department of Interventional Radiology, Department of Interventional Ultrasound, Chinese PLA General Hospital, 100853, Beijing, Shandong, China;Department of Medical Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China;

关键词: Lung metastasis;    Artificial pneumothorax;    Mediastinum;    Radiofrequency ablation;    Hepatocellular carcinoma;   

DOI  :  10.1186/s12885-021-08223-7

来源: Springer

【 摘 要 】

BackgroundTo investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificial pneumothorax technique.MethodA total of 40 lesions in 32 patients with pulmonary metastases from HCC contiguous with the mediastinum accepted RFA treatment from August 2014 to May 2018 via the artificial pneumothorax technique. After ablation, clinical outcomes were followed up by contrast enhanced CT. Technical success, local tumor progression (LTP), intrapulmonary distant recurrence (IDR), and adverse events were evaluated. Overall survival (OS) and local tumor progression free survival (LTPFS) were recorded for each patient.ResultsThe tumor size was 1.4 ± 0.6 cm in diameter. RFA procedures were all successfully performed without intra-ablative complications. Technical success was noted in 100% of the patients. Five cases of LTP and 8 cases of IDR occurred following the secondary RFA for treatment. Slight pain was reported in all patients. No major complications were observed. The 1, 2, and 3-year LTPFS rates were 90.6, 81.2, and 71.8%, and the 1, 2, and 3-year OS rates were 100, 100 and 87.5%, respectively.ConclusionArtificial pneumothorax adjuvant RFA is a feasible, safe, and efficient method for treatment of pulmonary metastases from HCC contiguous with the mediastinum.

【 授权许可】

CC BY