Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

Journal of Medical Case Reports

Didier Riethmuller¹  Claire Baeza¹  Edith Allam-Ndoul¹  Rajeev Ramanah¹ 

[1] Obstetrics and Gynecology Department, Besancon University Medical Centre, 3 Alexander Fleming Boulevard, 25000 Besancon, France

关键词: Lung metastasis;    Brain metastasis;    Bartholin’s gland;    Adenoid cystic carcinoma;   

Others  :  825654
DOI  :  10.1186/1752-1947-7-208

 received in 2013-02-24, accepted in 2013-06-11,  发布年份 2013

【 摘 要 】

Introduction

Adenoid cystic carcinoma of Bartholin’s gland is a very rare disease.

Case presentation

A 48-year-old premenopausal woman of Caucasian origin was delivered adjuvant pelvic and inguinal radiotherapy after prior complete left Bartholin’s gland tumor excision and inguinal lymph node dissection for adenoid cystic carcinoma of Bartholin’s gland with one metastatic inguinal lymph node.

Two years after primary treatment, she presented to the Emergency Room with acute headache, hypoacousia, decrease in visual acuity, and a decrease in right leg muscle strength. A cranial magnetic resonance imaging scan demonstrated three cystic brain lesions with associated perifocal edema. Chest and abdomen computed tomography scans and a magnetic resonance imaging scan of the pelvis did not find any metastatic or residual disease elsewhere. A physical examination found no local recurrence.

Stereotactic brain biopsies with pathology examination revealed the presence of adenoid cystic carcinoma metastasis. She thus received 30Gy of brain radiotherapy but, three months later, the brain lesions did not decrease in size and left mid lobular lung lesions appeared on her chest computed tomography scan. A mid left lobe lung excision was undertaken followed by chemotherapy consisting of six cycles of cyclophosphamide, adriamycin and cisplatin. Five months after beginning chemotherapy, the brain disease progressed and our patient died.

Conclusion

Our case report shows the difficulty in managing brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma as no consensus on the optimal treatment exists.

【 授权许可】

   
2013 Ramanah et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]DePasquale SE, McGuinness TB, Mangan CE, Husson M, Woodland MB: Adenoid cystic carcinoma of Bartholin’s gland: a review of the literature and report of a patient. Gynecol Oncol 1996, 61:122-125.
• [2]Nasu K, Kawano Y, Takai N, Kashima K, Miyakawa I: Adenoid cystic carcinoma of Bartholin’s gland. Case report with review of the literature. Gynecol Obstet Invest 2005, 59:54-58.
• [3]Lelle RJ, Davis KP, Roberts JA: Adenoid cystic carcinoma of the Bartholin’s gland: the University of Michigan experience. Int J Gynecol Cancer 1994, 4:145-149.
• [4]Yang SY, Lee JW, Kim WS, Jung KL, Lee SJ, Lee JH, Bae DS, Kim BG: Adenoid cystic carcinoma of the Bartholin’s gland: report of two cases and review of the literature. Gynecol Oncol 2006, 100:422-425.
• [5]Frable WJ, Goplerud DR: Adenoid cystic carcinoma of Bartholin’s gland diagnosis by aspiration biopsy. Acta Cytol 1975, 19:152-153.
• [6]Visco AG, Del Priore G: Postmenopausal Bartholin gland enlargement: a hospital-based cancer risk assessment. Obstet Gynecol 1996, 87:286-290.
• [7]Ramanah R, Lesieur B, Ballester M, Darai E, Rouzier R: Trends in of late-stage squamous cell vulvar carcinomas: analysis of the surveillance, epidemiology, and end results (SEER) database. Int J Gynecol Cancer 2012, 22:854-859.
• [8]Alsan CI, Vinh-Hung V, Eren F, Abacioglu U: Adenoid cystic carcinoma of the Bartholin’s gland: case report and systematic review of the literature. Eur J Gynaecol Oncol 2011, 32:567-572.
• [9]Hatiboglu MA, Cosar M, Iplikcioglu AC, Ozcan D: Brain metastasis from an adenoid cystic carcinoma of the Bartholin gland. Case report. J Neurosurg 2005, 102:543-546.
• [10]Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990, 322:494-500.
• [11]Abrao FS, Marques AF, Marziona F, Abrao MS, Uchoa Junqueira LC, Torloni H: Adenoid cystic carcinoma of Bartholin’s gland: review of the literature and report of two cases. J Surg Oncol 1985, 30:132-137.
• [12]Rose PG, Tak WK, Reale FR, Hunter RE: Adenoid cystic carcinoma of the vulva: a radiosensitive tumor. Gynecol Oncol 1991, 43:81-83.