No-touch Radiofrequency Ablation of VX2 Hepatic Tumor In Vivo in Rabbits: A proof of concept study

Radiofrequency ablation;no-touch RFA;direct tumor puncture RFA;peritoneal seeding;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Radiofrequency ablation;    no-touch RFA;    direct tumor puncture RFA;    peritoneal seeding;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/142343/1/000000151505.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Group C (n=12) as a control group. Each three groups were subdivided into two sets either for pathologic analysis (n=24) or CT follow-up until 6-weeks after RFA (n=38). Ultrasonography-guided dtpRFA and ntRFA were performed after nine days of tumor implantation. Local tumor control of RFA was determined by either achievement of complete tumor necrosis on histopathologic exam or absence of local tumor progression (LTP) on follow-up CT and autopsy. The development of peritoneal seeding was also compared among the animal groups. Serum hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) on day 1, day 2, and day 3 after RFA were measured by ELISA assay for tumorigenic factor evaluation.ResultsRegarding local tumor control, there was a trend with group B (80%, 20/25) for the better ablation than group A (56%, 14/25) (P=0.07). Complete tumor necrosis was achieved in 54.5% of group A animals (6/11) and 90.9% of group B animals (10/11). Peritoneal seeding after RFA was significantly more common in group A (71.4%, 10/14) than B (21.4%, 3/14) (P=0.021) or group C (0%). The elevation of HGF, VEGF and IL-6 were not detected in all three groups.ConclusionNtRFA developed lower rates of peritoneal seeding and showed a tendency to achieve better local tumor control compared to those of dtpRFA.