High dose versus low dose standardized cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection in healthy women: a double-blind randomized controlled trial

BMC Urology

Asma Babar¹  Sylvie Dodin²  Lynne Moore³  Valérie Bochard⁴  Denis Guyonnet⁵  Yves Desjardins⁶  Simone Lemieux⁶  Stéphanie Dudonné⁶  Vicky Leblanc⁶ 

[1] CHU de Québec-Laval University Research Center, Québec City, Canada;Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Québec City, Canada;CHU de Québec-Laval University Research Center, Québec City, Canada;Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Québec City, Canada;Department of Obstetrics and Gynecology, Saint-Francois D’Assise Hospital, Laval University, 10 Espinay Road, G1V 0A6, Québec City, Canada;Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Québec City, Canada;Diana Food, Rennes, France;Diana Nova, Paris, France;Institute of Nutrition and Functional Foods, Laval University, Québec City, Canada;

关键词: Women;    Urinary tract infections;    Proanthocyanidins;    Cranberry;    Prevention;   

DOI  :  10.1186/s12894-021-00811-w

来源: Springer

【 摘 要 】

PurposeOur objective was to assess the efficacy of a high dose cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection.Material and methodsWe recruited 145 healthy, adult women with a history of recurrent urinary tract infection, defined as ≥ 2 in the past 6 months or ≥ 3 in the past 12 months in this randomized, controlled, double-blind clinical trial. Participants were randomized to receive a high dose of standardized, commercially available cranberry proanthocyanidins (2 × 18.5 mg daily, n = 72) or a control low dose (2 × 1 mg daily, n = 73) for a 24-week period. During follow-up, symptomatic women provided urine samples for detection of pyuria and/or bacteriuria and received an appropriate antibiotic prescription. The primary outcome for the trial was the mean number of new symptomatic urinary tract infections during a 24-week intervention period. Secondary outcomes included symptomatic urinary tract infection with pyuria or bacteriuria.ResultsIn response to the intervention, a non-significant 24% decrease in the number of symptomatic urinary tract infections was observed between groups (Incidence rate ratio 0.76, 95%CI 0.51–1.11). Post-hoc analyses indicated that among 97 women who experienced less than 5 infections in the year preceding enrolment, the high dose was associated with a significant decrease in the number of symptomatic urinary tract infections reported compared to the low dose (age-adjusted incidence rate ratio 0.57, 95%CI 0.33–0.99). No major side effects were reported.ConclusionHigh dose twice daily proanthocyanidin extract was not associated with a reduction in the number of symptomatic urinary tract infections when compared to a low dose proanthocyanidin extract. Our post-hoc results reveal that this high dose of proanthocyanidins may have a preventive impact on symptomatic urinary tract infection recurrence in women who experienced less than 5 infections per year.Trial registration: Clinicaltrials.gov, identifier NCT02572895

【 授权许可】

CC BY