Medical Management of Drug-Resistant Tuberculosis

Tuberculosis and Respiratory Diseases

article

Doosoo Jeon¹ 

[1] Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine

关键词: Tuberculosis;    Drug Resistance;    Tuberculosis;    Multidrug-Resistant;    Extensively Drug-Resistant Tuberculosis;   

DOI  :  10.4046/trd.2015.78.3.168

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Drug-resistant tuberculosis (TB) is still a major threat worldwide. However, recent scientific advances in diagnostic and therapeutic tools have improved the management of drug-resistant TB. The development of rapid molecular testing methods allows for the early detection of drug resistance and prompt initiation of an appropriate treatment. In addition, there has been growing supportive evidence for shorter treatment regimens in multidrug-resistant TB; and for the first time in over 50 years, new anti-TB drugs have been developed. The World Health Organization has recently revised their guidelines, primarily based on evidence from a meta-analysis of individual patient data (n=9,153) derived from 32 observational studies, and outlined the recommended combination and correct use of available anti-TB drugs. This review summarizes the updated guidelines with a focus on the medical management of drug-resistant TB.

【 授权许可】

CC BY-NC