Multidrug-Resistant Tuberculosis Presenting as Miliary Tuberculosis without Immune Suppression: A Case Diagnosed Rapidly with the Genotypic Line Probe Assay Method

Tuberculosis and Respiratory Diseases

article

Yousang Ko¹  Ho Young Lee¹  Young Seok Lee¹  Junwhi Song²  Mi-Yeong Kim¹  Hyun-Kyung Lee¹  Jeong Hwan Shin³  Seok Jin Choi⁴  Young-Min Lee¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine;Department of Pulmonology, Samsung Changwon Medical Center, Sungkyunkwan University School of Medicine;Department of Laboratory Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine;Department of Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine

关键词: Tuberculosis;    Multidrug-Resistant;    Tuberculosis;    Miliary;    Molecular Probe Techniques;   

DOI  :  10.4046/trd.2014.76.5.245

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.

【 授权许可】

CC BY-NC