Signaling and other functions of lipids in autophagy: a review

Lipids in Health and Disease

Alejandro Soto-Avellaneda¹  Brad E. Morrison² 

[1] Biomolecular Sciences Graduate programs, Boise State University, 83725, Boise, ID, USA;Biomolecular Sciences Graduate programs, Boise State University, 83725, Boise, ID, USA;Department of Biological Sciences, Boise State University, 83725, Boise, ID, USA;

关键词: Autophagy;    Lipids;    Mammalian target of rapamycin;    Peroxisome proliferator-activated receptor;    Fatty acids;    Phospholipids;    Sphingolipids;   

DOI  :  10.1186/s12944-020-01389-2

来源: Springer

【 摘 要 】

The process of autophagy is integral to cellular function. In this process, proteins, organelles, and metabolites are engulfed in a lipid vesicle and trafficked to a lysosome for degradation. Its central role in protein and organelle homeostasis has piqued interest for autophagy dysfunction as a driver of pathology for a number of diseases including cancer, muscular disorders, neurological disorders, and non-alcoholic fatty liver disease. For much of its history, the study of autophagy has centered around proteins, however, due to advances in mass spectrometry and refined methodologies, the role of lipids in this essential cellular process has become more apparent. This review discusses the diverse endogenous lipid compounds shown to mediate autophagy. Downstream lipid signaling pathways are also reviewed in the context of autophagy regulation. Specific focus is placed upon the Mammalian Target of Rapamycin (mTOR) and Peroxisome Proliferator-Activated Receptor (PPAR) signaling pathways as integration hubs for lipid regulation of autophagy.

【 授权许可】

CC BY