The properties of MOF-Zn2(EBNB)2(BPY)2·2H2O and its basic study of loading methadone

BMC Chemistry

Li Song¹  Sun Xuehua²  Deng Linxin² 

[1] College of Science, Yunnan Agricultural University, 650201, Kunming, China;Department of Drug Control, Key Laboratory of Narcotics Assay and Control Technology Ministry of Public Security, Yunnan Police College, 650223, Kunming, China;

关键词: MOFs;    Methadone;    Drug loading;    Drug release;    Cytotoxicity;   

DOI  :  10.1186/s13065-020-00709-y

来源: Springer

【 摘 要 】

The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C16H10N2O8) were synthesized in three steps, and then the MOF-Zn2(EBNB)2(BPY)2·2H2O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn2(EBNB)2(BPY)2·2H2O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn2(EBNB)2(BPY)2·2H2O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn2(EBNB)2(BPY)2·2H2O has good biocompatibility.

【 授权许可】

CC BY