Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Bioactive Materials

Ximu Zhang¹  Yan Zhang²  Yu Shrike Zhang³  Hongmei Zhang³  Man Zhao³  Xiaoqiao Ning³  Menghong Wang³  Xiang Liu³  Jinlin Song⁴  Ke Xue⁵  Guo Ye⁶  Xiang Mao⁷ 

[1] Corresponding author.;Department of Plastic and reconstructive surgery, Hainan Western Central Hospital, HaiNan, 571700, China;Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China;Department of Pharmacy, The 958th Hospital of PLA, Chongqing, 404100, China;Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Rd, Shanghai, 200011, China;Department of Stomatology, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, 401120, China;State Key Laboratory of Ultrasound in Medicine and Engineering and Chongqing Key Laboratory of Biomedical Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China;

关键词: Andrias davidianus;    Hydrogel;    Drug loading;    Controlled drug delivery;    Stem cell recruitment;    Wound healing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Local drug delivery has received increasing attention in recent years. However, the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios, such as in the oral cavity or in wound beds after resection of tumors. In this study, we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus (SSAD) as a wound dressing for localized drug elution. The hydrogel was loaded with aminoguanidine or doxorubicin, and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model, respectively. The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing. Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites. Taken together, these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing.

【 授权许可】

Unknown