The maspin expression in canine mammary tumors: an immunohistochemical and molecular study

Pesquisa Veterinária Brasileira

Debora A.p.c. Zuccari²  Rodrigo Castro¹  Arieli F. Gavioli¹  Ulises M. Mancini¹  Eloisa H. Tajara¹  Cibelli S. Frade¹  Luana R. Pivaro¹  Juliana Carmona-raphe¹  Ana Carolina B. Terzian¹  Camila M. Ruiz¹  Eny M. Goloni Bertollo¹  Érika C. Pavarino-bertelli¹ 

[1] ,Faculdade de Medicina de São José do Rio Preto Centro Regional de Bioterismo São José do Rio Preto SP ,Brazil

关键词: Maspin;    canine mammary tumor;    immunohistochemistry;    molecular biology;    prognosis;    Maspin;    tumor mamário canino;    imuno-histoquímica;    biologia molecular;    prognóstico;   

DOI  :  10.1590/S0100-736X2009000200015

来源: SciELO

【 摘 要 】

The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia.

【 授权许可】

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