Pesquisa Veterinária Brasileira | |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study | |
Debora A.p.c. Zuccari2  Rodrigo Castro1  Arieli F. Gavioli1  Ulises M. Mancini1  Eloisa H. Tajara1  Cibelli S. Frade1  Luana R. Pivaro1  Juliana Carmona-raphe1  Ana Carolina B. Terzian1  Camila M. Ruiz1  Eny M. Goloni Bertollo1  Érika C. Pavarino-bertelli1  | |
[1] ,Faculdade de Medicina de São José do Rio Preto Centro Regional de Bioterismo São José do Rio Preto SP ,Brazil | |
关键词: Maspin; canine mammary tumor; immunohistochemistry; molecular biology; prognosis; Maspin; tumor mamário canino; imuno-histoquímica; biologia molecular; prognóstico; | |
DOI : 10.1590/S0100-736X2009000200015 | |
来源: SciELO | |
【 摘 要 】
The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia.
【 授权许可】
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