Química Nova | |
Quantificação simultânea de indicadores biológicos de exposição a solventes orgânicos por cromatografia líquida de alta eficiência | |
Rachel Bulcão2  Lucas Santa Maria2  Mariele Charão2  Angela Moro2  Miguel Roehrs2  Solange Cristina Garcia2  Renata Pereira Limberger1  | |
[1] ,Universidade Federal de Santa Maria Departamento de Análises Clínicas e Toxicológicas Santa Maria RS ,Brasil | |
关键词: HPLC; organic solvents; biological exposure index; | |
DOI : 10.1590/S0100-40422008000600013 | |
来源: SciELO | |
【 摘 要 】
Biological monitoring is very important to guarantee health to workers. This method was developed for simultaneous determination of xylene, toluene, styrene and ethylbenzene metabolites. It involves only dilution and centrifugation of urine samples and improved chromatographic conditions. Analyses show recovery > 95%; r² > 0.99; intermediate precision CV% < 6% and % bias < ±10. Exposed subjects presented at least three metabolites in urine. The method proved to be feasible, reliable and important in biological monitoring, especially in exposure to organic solvent mixtures.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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