Simultaneous quantification of organic solvent biomarkers by high performance liquid chroma tography

Quimica nova

Limberger, Renata Pereira¹  Roehrs, Miguel²  Garcia, Solange Cristina²  Maria, Lucas Santa²  Bulcão, Rachel²  Charão, Mariele²  Moro, Angela² 

[1] Universidade Federal de Santa Maria, Porto Alegre, Brasil;Universidade Federal de Santa Maria, Santa Maria, Brasil

关键词: HPLC;    organic solvents;    biologicalexposure index.;   

DOI  :  10.1590/S0100-40422008000600013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Biological monitoring is very important to guaranteehealth to workers. This method was developed for simultaneous determinationof xylene, toluene, styrene and ethylbenzene metabolites. It involves only dilutionand centrifugation of urine samples and improved chromatographic conditions.Analyses show recovery > 95%; r2 > 0.99; intermediateprecision CV% < 6% and % bias < ±10. Exposed subjects presented at leastthree metabolites in urine. The method proved to be feasible, reliable and importantin biological monitoring, especially in exposure to organic solvent mixtures.

【 授权许可】

CC BY