Quantificação simultânea de indicadores biológicos de exposição a solventes orgânicos por cromatografia líquida de alta eficiência

Química Nova

Rachel Bulcão²  Lucas Santa Maria²  Mariele Charão²  Angela Moro²  Miguel Roehrs²  Solange Cristina Garcia²  Renata Pereira Limberger¹ 

[1] ,Universidade Federal de Santa Maria Departamento de Análises Clínicas e Toxicológicas Santa Maria RS ,Brasil

关键词: HPLC;    organic solvents;    biological exposure index;   

DOI  :  10.1590/S0100-40422008000600013

来源: SciELO

【 摘 要 】

Biological monitoring is very important to guarantee health to workers. This method was developed for simultaneous determination of xylene, toluene, styrene and ethylbenzene metabolites. It involves only dilution and centrifugation of urine samples and improved chromatographic conditions. Analyses show recovery > 95%; r² > 0.99; intermediate precision CV% < 6% and % bias < ±10. Exposed subjects presented at least three metabolites in urine. The method proved to be feasible, reliable and important in biological monitoring, especially in exposure to organic solvent mixtures.

【 授权许可】

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