Simultaneous quantification of organic solvent biomarkers by high performance liquid chroma tography

Química Nova

Roehrs, Miguel¹  Garcia, Solange Cristina¹  Maria, Lucas Santa¹  Limberger, Renata Pereira¹  Universidade Federal de Santa Maria, Porto Alegre, Brasil¹  Universidade Federal de Santa Maria, Santa Maria, Brasil¹  Bulcão, Rachel¹  Charão, Mariele¹  Moro, Angela¹ 

关键词: HPLC;    organic solvents;    biological exposure index.;   

DOI  :  10.1590/S0100-40422008000600013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Biological monitoring is very important to guarantee health to workers. This method was developed for simultaneous determination of xylene, toluene, styrene and ethylbenzene metabolites. It involves only dilution and centrifugation of urine samples and improved chromatographic conditions. Analyses show recovery > 95%; r2 > 0.99; intermediate precision CV% < 6% and % bias < ±10. Exposed subjects presented at least three metabolites in urine. The method proved to be feasible, reliable and important in biological monitoring, especially in exposure to organic solvent mixtures.

【 授权许可】

Unknown