p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma

Revista do Instituto de Medicina Tropical de São Paulo

Venâncio Avancini Ferreira Alves²  Marcelo Eidi Nita¹  Flair José Carrilho¹  Suzane Kioko Ono-nita¹  Alda Wakamatsu²  Dárcio Matenhauer Lehrbach¹  Maria Fernanda Pimentel De Carvalho¹  Evandro Sobroza De Mello²  Luiz Carlos Da Costa Gayotto²  Luiz Caetano Da Silva¹ 

[1] ,São Paulo University Adolfo Lutz Institute School of Medicine & Immunohistochemistry LaboratorySão Paulo SP ,Brazil

关键词: Liver cancer;    p53;    Cell cycle;    Apoptosis;    Hepatitis B;    Hepatitis C;    Immunohistochemistry;   

DOI  :  10.1590/S0036-46652004000100005

来源: SciELO

【 摘 要 】

Hepatocellular carcinoma (HCC) is an important type of cancer etiologically related to some viruses, chemical carcinogens and other host or environmental factors associated to chronic liver injury in humans. The tumor suppressor gene p53 is mutated in highly variable levels (0-52%) of HCC in different countries. OBJECTIVE: The objective of the present study was to compare the frequency of aberrant immunohistochemical expression of p53 in HCC occurring in cirrhotic or in non-cirrhotic patients as well as in liver cell dysplasia and in adenomatous hyperplasia. We studied 84 patients with HCC or cirrhosis. RESULTS: We detected p53 altered immuno-expression in 58.3% of patients in Grade III-IV contrasting to 22.2% of patients in Grade I-II (p = 0.02). Nontumorous areas either in the vicinity of HCC or in the 30 purely cirrhotic cases showed no nuclear p53 altered expression, even in foci of dysplasia or adenomatous hyperplasia. No significant difference was found among cases related to HBV, HCV or alcohol. CONCLUSION: The high frequency of p53 immunoexpression in this population is closer to those reported in China and Africa, demanding further studies to explain the differences with European and North American reports.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License