Molecular aspects of hepatic carcinogenesis

Revista do Instituto de Medicina Tropical de São Paulo

Marcelo Eidi Nita²  Venâncio Avancini Ferreira Alves¹  Flair José Carrilho²  Suzane Kioko Ono-nita²  Evandro Sobroza De Mello¹  Joaquim J. Gama-rodrigues¹ 

[1] ,University of São Paulo School of Medicine Department of GastroenterologySão Paulo SP ,Brazil

关键词: Liver cancer;    Carcinogenesis;    Hepatitis B;    Hepatitis C;    p53;    Cell cycle;    Apoptosis;   

DOI  :  10.1590/S0036-46652002000100007

来源: SciELO

【 摘 要 】

Exogenous agents correlated with hepatocellular carcinoma (HCC) have been identified and well characterized. These agents, including the different viruses that cause chronic hepatitis and cirrhosis, can lead to regenerative nodules and dysplastic nodules/adenomatous hyperplasia. These conditions associated with several molecular alterations of hepatocyte ultimately culminate in hepatocellular carcinoma. Recently, there has been a great progress in the identification of somatic and germinative mutations that may be correlated with the development of HCC, justifying a review on the subject. Hence, the factors involved in the process of hepatic carcinogenesis, such as infection by the hepatitis B and C viruses, with a special focus in the molecular alterations described in recent years are discussed herein, pointing out areas potentially relevant for clinical development.

【 授权许可】

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