Dementia Pugilistica with clinical features of Alzheimer's disease

Arquivos de Neuro-Psiquiatria

Renata Areza-fegyveres²  Sergio Rosemberg¹  Rosa Maria R.p.s. Castro¹  Claudia Sellitto Porto²  Valéria Santoro Bahia²  Paulo Caramelli²  Ricardo Nitrini² 

[1] ,University of São Paulo School of Medicine Department of NeurologySão Paulo SP ,Brazil

关键词: dementia;    dementia pugilistica;    punch drunk;    Alzheimer's disease;    chronic traumatic encephalopathy;    parkinsonian;    neuropathology;    demência;    dementia pugilistica;    síndrome punch-drunk;    doença de Alzheimer;    encefalopatia traumática crônica;    sinais motores;    neuropatologia;   

DOI  :  10.1590/S0004-282X2007000500019

来源: SciELO

【 摘 要 】

A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease.

【 授权许可】

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