Brazilian Journal of Microbiology | |
Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata | |
Karina Andrade De Prince1  Renata Sordi1  Fernando Rogério Pavan1  Adolfo Carlos Barreto Santos1  Angela R. Araujo1  Sergio R.a. Leite1  Clarice Q. F. Leite1  | |
[1] ,Universidade Estadual PaulistaAraraquara SP ,Brasil | |
关键词: Phomopsis stipata; antimycobacterial activity; Mycobacterium tuberculosis; | |
DOI : 10.1590/S1517-83822012000100024 | |
来源: SciELO | |
【 摘 要 】
Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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