Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test

Revista Brasileira de Farmacognosia

Suzana G. Leitão²  Oscar Castro¹  Eduardo N. Fonseca²  Lisieux S. Julião¹  Eliana S. Tavares¹  Rodrigo R.t. Leo¹  Ricardo C. Vieira¹  Danilo R. Oliveira¹  Gilda G. Leitão¹  Virginia Martino¹  Valeria Sulsen¹  Ymira A.g. Barbosa²  Diva P.g. Pinheiro²  Pedro E. Almeida Da Silva¹  Dulcineia F. Teixeira¹  Ivan N. Junior¹  Maria Cristina S. Lourenço¹ 

[1] ,Universidade Federal do Rio de Janeiro Faculdade de Farmácia Departamento de Produtos Naturais e AlimentosRio de Janeiro RJ ,Brazil

关键词: Mycobacterium tuberculosis;    Lantana trifolia;    Vitex cooperi;    Lippia lacunosa;    Lippia rotundifolia;    antimycobacterial activity;    20-hydroxyecdysone;    Mycobacterium tuberculosis;    Lantana trifolia;    Vitex cooperi;    Lippia lacunosa;    Lippia rotundifolia;    atividade antimicobacteriana;    20-hidroxi-ecdisona;   

DOI  :  10.1590/S0102-695X2006000100003

来源: SciELO

【 摘 要 】

Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License