Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test

Revista Brasileira de Farmacognosia

Pinheiro, Diva P.G.¹  Oliveira, Danilo R.¹  Sulsen, Valeria¹  Universidad de Buenos Aires, Buenos Aires, Argentina¹  Fonseca, Eduardo N.¹  Leitão, Gilda G.¹  Julião, Lisieux S.¹  Fiocruz, Rio de Janeiro, Brazil¹  Universidad Nacional, Heredia, Costa Rica¹  N. Junior, Ivan¹  Silva, Pedro E. Almeida da¹  UBA¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Castro, Oscar¹  Teixeira, Dulcineia F.¹  Fiocruz, Rio de Janeiro, Brasil¹  Tavares, Eliana S.¹  Leitão, Suzana G.¹  Vieira, Ricardo C.¹  Leo, Rodrigo R.T.¹  Fundação Universidade Federal do do Rio Grande, Rio Grande do Sul, Brazil¹  Lourenço, Maria Cristina S.¹  Martino, Virginia¹  Barbosa, Ymira A.G.¹ 

关键词: Mycobacterium tuberculosis;    Lantana trifolia;    Vitex cooperi;    Lippia lacunosa;    Lippia rotundifolia;    antimycobacterial activity;    20-hydroxyecdysone.;   

DOI  :  10.1590/S0102-695X2006000100003

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.

【 授权许可】

Unknown