Association between level of interferon gamma and acid-fast bacillipositivity in pulmonary tuberculosis

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Priwahyuningtyas, N.B.^1 ; Sinaga, B.Y.M.^1 ; Pandia, P.^1 ; Eyanoer, P.C.^2

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Kampus USU Padang Bulan, Medan

20155, Indonesia^1

Department of Community Medicine, Faculty of Medicine, Universitas Sumatera Utara, Kampus USU Padang Bulan, Medan

20155, Indonesia^2

关键词: Bacterial infections;    Case-control study;    Infectious disease;    Interferon-gamma;    Level of interferons;    M. tuberculosis;    Mycobacterium tuberculosis;    Pulmonary tuberculosis;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012152/pdf
DOI  :  10.1088/1755-1315/125/1/012152

来源: IOP

【 摘 要 】

Tuberculosis is an infectious disease which caused by Mycobacterium tuberculosis (M. tuberculosis) that infected numerous organ especially the lung. A person's immunity is very affecting for a person exposed to pulmonary tuberculosis. T-helper-1 cell (Th1) is very influential in the immune system especially in interfering intracellular bacterial infection. One of the cytokines known produced by Th1 cell is interferon gamma (IFN-γ) which is in eliminating M. tuberculosis. The study aims to identify the association between level of IFN-γ and AFB positivity in pulmonary tuberculosis patients in Medan. It is a case-control study. The subjects of the study were 60 new cases of pulmonary tuberculosis with AFB sputum smear- positive that never received ATT consisting 20 cases AFB (+1), 20 cases AFB (+2) and 20 cases AFB (+3).Samples were plasma collected from the venous blood of pulmonary tuberculosis patients. The plasma then underwent laboratory assay with ELISA techniques. Independent t-test was p