Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives

Journal of the Brazilian Chemical Society

Roberta C. N. Reis¹  Simone C. Oda¹  Mauro V. De Almeida¹  Maria C. S. Lourenço²  Felipe R. C. Vicente²  Nadia R. Barbosa²  Rafael Trevizani²  Priscila L. C. Santos²  Mireille Le Hyaric¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG ,Brazil

关键词: antimicrobial;    M. tuberculosis;    amphiphilic;    aldonamide;   

DOI  :  10.1590/S0103-50532008000600003

来源: SciELO

【 摘 要 】

N-monoalkylated diamines were synthesised and treated with D-ribonolactone or D-gluconolactone. The resulting aldonamides were evaluated for their antimicrobial activity against S. aureus, E. coli, M. tuberculosis and C. albicans. Two hydrazides were also prepared from ribonohydrazide and their biological activity was compared to their amide analogues. All the ribono-derivatives displayed moderated antitubercular activity, and some of them were also active against S. aureus.

【 授权许可】

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