1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara | |
The influence of mutation gene rpoB of Mycobacterium tuberculosis cluster I (507-534) on the elimination 25-desacetyl rifampicin in urine of tuberculosis subjects | |
Lily^1 ; Sinaga, B.Y.M.^2 ; Ardinata, D.^3 ; Siregar, Y.^4 | |
Master of Biomedical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Medan | |
20155, Indonesia^1 | |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, RSUP. Haji Adam Malik, Medan | |
20136, Indonesia^2 | |
Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan | |
20155, Indonesia^3 | |
Department of Biomedical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Medan | |
20155, Indonesia^4 | |
关键词: Confidence interval; Distributed data; Fixed-dose combination; M. tuberculosis; Mycobacterium tuberculosis; P-values; Shapiro-Wilk tests; Standard deviation; | |
Others : https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012146/pdf DOI : 10.1088/1755-1315/125/1/012146 |
|
来源: IOP | |
【 摘 要 】
The study aimed to evaluate the influence of mutation gene rpoB of Mycobacterium (M.) tuberculosis cluster I (507-534) on the elimination of 25-Desacetyl Rifampicin (25-DR) in the urine of tuberculosis (TB) subjects. Early morning sputum took from patient TB before treatment. Urine collected after 2 hours taken Fixed-Dose Combination (FDC) at days 7thtreatment. All sputum were sequencing at Macrogen Korea Laboratory. Urine was analyzed by high-Performance Liquid Chromatography (HPLC) using the method of Lily et al. Mean (standard deviation) for mutation and non-mutation of rpoB M. tuberculosis group were 7.6147 (4.4478) and 4.5772 (1.7532) μg/ml, respectively. Shapiro-Wilk test showed normally distributed data, with significance 0.3. Independent t-test performed p-value 0.167 and confidence interval (CI) from -1.648 to 7.723. The mutation gene rpoB of M. tuberculosis cluster, I (507-534) in this study, did not affect elimination 25-DR in theurine of TB subjects statistically and clinically.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
The influence of mutation gene rpoB of Mycobacterium tuberculosis cluster I (507-534) on the elimination 25-desacetyl rifampicin in urine of tuberculosis subjects | 214KB | download |