Assessing Amphiphilic ABAB Zn(II) Phthalocyanines with Enhanced Photosensitization Abilities in In Vitro Photodynamic Therapy Studies Against Cancer

Molecules

Ángeles Juarranz¹  Tomás Torres¹  Marta Mascaraque¹  Arturo González-Camuñas¹  MiguelÁ. Revuelta-Maza¹  Gema de la Torre¹  Patricia González-Jiménez¹  Santi Nonell² 

[1] Departments of Organic Chemistry and Biology, Universidad Autónoma de Madrid. C/Francisco Tomás y Valiente 7, 28049 Madrid, Spain;Institut Químic de Sarrià. Universitat Ramon Llull, 08017 Barcelona, Spain;

关键词: zn(ii) phthalocyanines;    abab;    amphiphilic;    photodynamic therapy;    hela;    scc-13;   

DOI  :  10.3390/molecules25010213

来源: DOAJ

【 摘 要 】

We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., bis(trifluoromethyl)phenyl units) at facing positions of ABAB Zn(II)Pcs, where A and B refer to differently functionalized isoindoles. In this work, we have prepared the Zn(II)Pc ABAB 1 endowed with hydrophilic triethylene glycol monomethyl ether (i.e., at the A isoindoles) to provide solubility in aqueous media, together with its A₃B and A₄ counterparts, and compared their ability to behave as photosensitizers for photodynamic therapy. All photophysical data, aggregation studies and preliminary in vitro biological assays in cell cultures of SCC-13 (squamous cell carcinoma) and HeLa (cervical cancer cells), have proved ABAB 1 as the best photosensitizer of the series.

【 授权许可】

Unknown