Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species

Revista Brasileira de Farmacognosia

Pierre André De Souza²  Clara Rodrigues¹  Ana Paula S. A. Santiago¹  Nanci Camara De Lucas²  Gilda Guimaraes Leitao¹  Antonio Galina Filho¹ 

[1] ,Universidade Federal do Rio de Janeiro Departamento de Química Orgânica, Laboratório de Fotoquímica Rio de Janeiro RJ ,Brazil

关键词: Satchytarpheta cayennensis;    antioxidants;    mitochondria;    reactive oxygen species;    fluorescent probes;   

DOI  :  10.1590/S0102-695X2011005000050

来源: SciELO

【 摘 要 】

The etiology of a range of diseases is associated with an excessive generation of reactive oxygen species (ROS). Exacerbated ROS production leads to mitochondrial dysfunction, cellular damage and apoptosis. Nowadays, many strategies are being developed for the targeted delivery of antioxidants compounds to mitochondria, trying to minimize the damages. Production of ROS was investigated by the molecular probes CM-H2DCFDA and Amplex Red. The purpose of this work is to evaluate the antioxidant capacity of verbascoside, martinoside, betulinic acid from the Stachytarpheta cayennensis and quercetin by an in vitro assay with isolated mitochondria from mice's brain The results showed that all compounds tested exhibited a scavenger effect on the ROS generated by the isolated mitochondria, which displayed a dependent dose increase.

【 授权许可】

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