Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species

Revista Brasileira de Farmacognosia

Lucas, Nanci Camara de¹  Leitao, Gilda Guimaraes¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Souza, Pierre André de¹  Santiago, Ana Paula S. A.¹  Rodrigues, Clara¹  Galina Filho, Antonio¹ 

关键词: Satchytarpheta cayennensis;    antioxidants;    mitochondria;    reactive oxygen species;    fluorescent probes;   

DOI  :  10.1590/S0102-695X2011005000050

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The etiology of a range of diseases is associated with an excessive generation of reactive oxygen species (ROS). Exacerbated ROS production leads to mitochondrial dysfunction, cellular damage and apoptosis. Nowadays, many strategies are being developed for the targeted delivery of antioxidants compounds to mitochondria, trying to minimize the damages. Production of ROS was investigated by the molecular probes CM-H2DCFDA and Amplex Red. The purpose of this work is to evaluate the antioxidant capacity of verbascoside, martinoside, betulinic acid from the Stachytarpheta cayennensis and quercetin by an in vitro assay with isolated mitochondria from mice's brain The results showed that all compounds tested exhibited a scavenger effect on the ROS generated by the isolated mitochondria, which displayed a dependent dose increase.

【 授权许可】

Unknown