blaCTX-M-2 and blaCTX-M-28 extended-spectrum β-lactamase genes and class 1 integrons in clinical isolates of Klebsiella pneumoniae from Brazil

Memórias do Instituto Oswaldo Cruz

Ana Catarina S Lopes¹  Dyana Leal Veras²  Alexsandra Mariá S Lima²  Rita De Cássia Andrade Melo¹  Juan Ayala¹ 

[1] ,Universidade Federal de Pernambuco Laboratório de Imunopatologia Keizo Asami Recife PE ,Brasil

关键词: Klebsiella pneumoniae;    blaCTX-M;    integrons;    multidrug resistance;   

DOI  :  10.1590/S0074-02762010000200009

来源: SciELO

【 摘 要 】

Twenty-eight Klebsiella pneumoniae clinical isolates that exhibited an extended-spectrum cephalosporin-resistance profile from a city in the Northeast of Brazil were analysed by PCR and DNA sequencing in order to determine the occurrence of blaCTX-M genes and class 1 integrons. We determined the occurrence of the blaCTX-M-2 gene in six K. pneumoniae isolates and describe the first detection of the blaCTX-M-28 gene in South America. Seven isolates carried class 1 integrons. Partial sequencing analysis of the 5'-3'CS variable region in the class 1 integrons of three isolates revealed the presence of aadA1, blaOXA-2 and dfr22 gene cassettes.

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