Synthesis, antioxidant and antibacterial activities of 3-nitrophenyl ferrocene

International Conference on Functional Materials and Chemical Engineering 2017

材料科学;化学工业

Benabdesselam, S.^1 ; Izza, H.^2 ; Lanez, T.^3 ; Guechi, E.K.^4

Laboratoire de Génie de l'Eau et de l'Environnement en Milieu Saharien, Faculty of Applied Sciences, University of Ouargla, Ouargla, Algeria^1

Laboraoitre de Génie des Procédés, Faculty of Applied Sciences, University of Ouargla, Ouargla, Algeria^2

Laboratory of Valorisation and Technology of Saharan Resources, University of El-Oued, El-oued, Algeria^3

Laboratory of Environmental Engineering, Faculty of Engineering, University of Annaba, Annaba, Algeria^4

关键词: Anti-bacterial activity;    Anti-oxidant activities;    Bacterial strains;    Enterococcus faecalis;    Klebsiella pneumoniae;    Pseudomonas aeruginosa;    Scavenging effect;    Superoxide radical;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/323/1/012007/pdf
DOI  :  10.1088/1757-899X/323/1/012007

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The current work aims in its first part to synthesize 3-nitrophenylferrocene after diazotizing nitroaniline in the meta position by the sodium nitrite and the formation of the corresponding diazonium salt: 3-nitrobenzendiazonium sulfate, then the salt in solution was added to the ferrocene for the purpose of introducing the nitrophenyl moiety thereon (arylation) and the formation of 3-nitrophenylferrocene. The second part is devoted to the study of the antioxidant activity of 3-NPF by applying the trapping test of superoxide radical using cyclic voltammetry, the free radical DPPH trapping test by spectrophotometry. The results showed that 3-nitrophenylferrocene has a scavenging effect of DPPH radical with IC50 = 1.44mg/ml, superoxide radical with IC50=5.38mg/ml. The third part is devoted to the study of antibacterial activity of the synthesized compound tested on four strains of bacteria: Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Klebsiella pneumoniae. The obtained results clearly showed that 3-nitrophenylferrocene has low activities on the four bacterial strains with diameters of inhibition zones do not exceeding 17 mm at concentrations of 25mg/ml.