Circulating miR-26a-1, miR-146a and miR-199a-1 are potential candidate biomarkers for acute myocardial infarction

Molecular Medicine

Sheng Xue¹  Peifeng Li¹  Wenjie Zhu²  Qing Chang²  Zhe Su²  Liwei Zhang²  Dacheng Liu² 

[1] 0000 0001 0455 0905, grid.410645.2, Institute for Translational Medicine, College of Medicine, Qingdao University, 266021, Qingdao, China;grid.412521.1, Affiliated Hospital of Qingdao University. Qingdao University, 266003, Qingdao, China;

关键词: Circulating miRNA;    Acute myocardial infarction;    Percutaneous coronary intervention;    Biomarker;   

DOI  :  10.1186/s10020-019-0086-1

来源: publisher

【 摘 要 】

BackgroundAcute myocardial infarction (AMI) was considered to be one of the major causes of morbidity and mortality worldwide. In order to manage the acute myocardial infarction outbreaks, accurate biomarkers for risk prediction are needed. Circulating microRNAs (miRNAs) may act as diagnostic and prognostic biomarkers for cardiovascular events.MethodsThis study aimed to determine the possibility of circulating miRNAs used as biomarkers for AMI and their dynamic expression levels before and after percutaneous coronary intervention (PCI) in patients. Circulating miR-26a-1, miR-27a, miR-30d, miR-146a, miR-199a-1 and miR-423 were selected and validated in 31 AMI patients and 27 matched controls by quantitative real-time PCR (qPCR).ResultsThe expression levels of plasma miR-26a-1, miR-146a and miR-199a-1 were significantly increased in AMI patients. Receiver operating characteristic (ROC) analysis indicated that miR-26a-1, miR-146a and miR-199a-1 showed considerable diagnostic efficiency for predicting AMI. Furthermore, we demonstrated that the combination of miR-26a-1, miR-146a and miR-199a-1 facilitated AMI diagnosis.ConclusionsOur findings suggest that circulating miR-26a-1, miR-146a and miR-199a-1 have the potential to be used as biomarkers for AMI diagnosis.

【 授权许可】

CC BY