Isolation of Araguspongine M, a New Stereoisomer of an Araguspongine/Xestospongin alkaloid, and Dopamine from the Marine Sponge Neopetrosia exigua Collected in Palau

Marine Drugs

Hongwei Liu³  Yuri Mishima³  Takeshi Fujiwara³  Hiroshi Nagai³  Akira Kitazawa³  Yuji Mine³  Hisayoshi Kobayashi²  Xinsheng Yao⁴  Junko Yamada¹  Taiko Oda¹ 

[1] Kyoritsu College of Pharmacy, Minato-ku, Tokyo 105-8512, Japan;Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan;Department of Ocean Sciences and T/R Vessel Shin’yo Maru, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan;Department of Natural Products, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, People’s Republic of China

关键词: Marine sponge;    Neopetrosia exigua;    araguspongine/xestospongin alkaloid;    cytotoxicity;    HL-60;   

DOI  :  10.3390/md204154

来源: mdpi

【 摘 要 】

A new stereoisomer of an araguspongine/xestospongin alkaloid, named araguspongine M (1), has been isolated together with 12 known compounds, araguspongines B (2) and D (3), dopamine, three galactosyl diacylglycerols, 24-methyl cholesterol, 5,6-dihydrocholesterol, β-sitosterol, and three 5α,8α-epidioxy sterols (11–13), from the marine sponge Neopetrosia exigua (formerly Xestospongia exigua) collected in Palau. The structure of 1 was assigned on the basis of its spectral data analysis. This is the first report on the isolation of dopamine from a marine sponge. This compound may be produced by an endosymbiotic Synechococcus-like cyanobacterium. Compounds 1–3 and 11–13 showed cytotoxicity against HL-60 at IC₅₀’s of 5.5, 5.5, 5.9, 22.4, 9.5, and 9.6 μM, respectively. The possible biosynthesis origin of the isolated metabolites is discussed.

【 授权许可】

Unknown   
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