Cytotoxic Aaptamines from Malaysian Aaptos aaptos

Marine Drugs

Khozirah Shaari¹  Kee Cheng Ling¹  Zalilawati Mat Rashid²  Tan Pei Jean¹  Faridah Abas¹  Salahudin Mohd. Raof¹  Zurina Zainal¹  Nordin Hj. Lajis¹  Habsah Mohamad² 

[1] Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia

关键词: Marine sponge;    Aaptos aaptos;    aaptaminoids;    alkaloids;    cytotoxicity;   

DOI  :  10.3390/md7010001

来源: mdpi

【 摘 要 】

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland