Araguspongine: an indole alkaloid as panc-1 cell inhibitory adapted to nutrient starvation from Indonesian's marine sponge spongionellapulchella

International Conference on Fisheries, Aquatic, and Environmental Sciences 2018

地球科学;农业科学;生态环境科学

Kurnianda, V.^1,2,3 ; Syahliza, F.^1 ; Karina, S.^1 ; Agustina, S.^1 ; Ulfah, M.^1 ; Octavina, C.^1 ; Mardiah, A.^1 ; Ramadhan, M.R.^1 ; Purnawan, S.^1

Department of Marine Science, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh

23111, Indonesia^1

Marine Chemistry Laboratory, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh

23111, Indonesia^2

Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa

903-0213, Japan^3

关键词: Active compounds;    Active metabolites;    FT-IR spectrum;    Indole alkaloids;    Marine sponge;    Nutrient-starvation;    Potential activities;    Secondary amines;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/216/1/012041/pdf
DOI  :  10.1088/1755-1315/216/1/012041

来源: IOP

【 摘 要 】

Isolation of active metabolite from Indonesian's Marine Sponge Spongionellapulchella has been conducted on July 2018. Active compound isolated based on bioassay-guided separation with several steps of chromatography. The rate of viability shows that IC50 = 0.2 μg / mL against PANC-1 cell. The active compound know as C28H51N2O2 determined by LCMS-ESI with molecular weight [M+H]+447.3951m/z. Based on the FTIR spectrum shows that the active metabolite has functional groups at 3435.56 cm1 as N-H secondary amines, 2853.39 cm1 as C-H methyl, 2769.64 cm1 as C-H methylene and the fingerprint region of amine at 1637.27 cm1 as C-N imine. The active compound which knows as araguspongine, an indole alkaloid shows potential activity against PANC-1 cell.