Inhibitory of PANC-1 produced by Indonesian's Marine Sponge Endectyon delaubenfelsi Adapted to Nutrient Starvation

International Conference on Fisheries, Aquatic, and Environmental Sciences 2018

地球科学;农业科学;生态环境科学

Mardiah, A.^1 ; Karina, S.^1 ; Agustina, S.^1 ; Ulfah, M.^1 ; Octavina, C.^1 ; Syahliza, F.^1 ; Ramadhan, M.R.^1 ; Purnawan, S.^1 ; Kurnianda, V.^1,2,3

Department of Marine Science, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh

23111, Indonesia^1

Marine Chemistry Laboratory, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh

23111, Indonesia^2

Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa

903-0213, Japan^3

关键词: Active compounds;    Active metabolites;    Amine functional groups;    Drug discovery;    FT-IR spectrum;    Marine sponge;    Nutrient-starvation;    Potential activities;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/216/1/012032/pdf
DOI  :  10.1088/1755-1315/216/1/012032

来源: IOP

【 摘 要 】

The bioactivity of Indonesian Marine Sponge Endectyon delaubenfelsi has been conducted on July 2018. The active metabolite based on bioassay guided-separation with several steps of chromatography. The FTIR spectrum shows that the active metabolite has N-H amine functional groups at 3434.6 cm-1 C-H methyl was detected at 3090.46 cm-1, and the fingerprint region at 1637.27 cm-1 as C-N imine. Based on the FTIR data shows indicate that the active compound as alkaloid. Metabolite active has activity IC50 = 0.2 ug / mL indicates that the active compound from of Endectyon delaubenfelsi has potential activity as the new model to the drug discovery against PANC-1 cell.