Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Marine Drugs

Baoquan Bao²  Ping Zhang²  Yoonmi Lee²  Jongki Hong¹  Chong-O. Lee³ 

[1] College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea;College of Pharmacy, Pusan National University, Busan 609-735, Korea;Korea Research Institute of Chemical Technology, Daejon 305-343, Korea

关键词: Marine sponge;    Spongosorites;    monoindole alkaloids;    cytotoxicity;   

DOI  :  10.3390/md502031

来源: mdpi

【 摘 要 】

Seven (1–7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1–5 are unique indole pyruvic acid derivatives. Compounds 1–2 and 4–6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.

【 授权许可】

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