Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

Marine Drugs

Jaine H. H. L. de Oliveira⁵  Mirna H. R. Seleghim⁵  Christoph Timm⁴  Achim Grube⁴  Matthias Kཬk⁴  Gislene G.F. Nascimento³  Ana Claudia T. Martins³  Elissa G. O. Silva³  Ana Olívia de Souza¹  Paulo R. R. Minarini¹  Fabio C. S. Galetti²  Célio L. Silva²  Eduardo Hajdu⁶ 

[1] Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil. (E.mail: olí;Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. (E-mail:;Faculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracaba, SP, Brazil. (E-mail:;Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12,D-27570 Bremerhaven, Germany. (E-mail:;Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil. (E-mail:;Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil. (E-mail:

关键词: alkaloids;    antimycobacterial;    antibacterial;    Pachychalina sp.;    sponge;   

DOI  :  10.3390/md401001

来源: mdpi

【 摘 要 】

Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines.

【 授权许可】

Unknown   
© 2006 by MDPI