Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans

Heterocyclic communications

article

N.H. Kumar Baba¹  D. Ashok³  Boddu Ananda Rao³  Sarasija Madderla⁴  N.Y.S. Murthy⁵ 

[1] Department of Chemistry, Jawaharlal Nehru Technological University;Chemveda Life Sciences India Pvt Ltd.;Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University;Department of Chemistry, Satavahana University;Department of Chemistry, Anurag Group of Institutions

关键词: antibacterial;    antimycobacterial;    benzofuran;    microwave irradiation;    thiazole;   

DOI  :  10.1515/hc-2017-0247

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

New thiazole-substituted dibenzofurans 7a–j were synthesized from dibenzofuran derivatives 5a–b and substituted thiosemicarbazones 6a–h under conventional and microwave irradiation conditions. The structures of all products were established on the basis of analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative strains. Compounds 7b, 7d and 7h are active against Bacillus subtilis (+ve), and compound 7i displays good activity against Pseudomonas aeruginosa (-ve) strain. Compounds 7a–j were also evaluated for their in vitro antimycobacterial activity, and compound 7b shows antimycobacterial activity against Mycobacterium bovis strain.

【 授权许可】

CC BY|CC BY-NC-ND