Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

Molecules

Chen-Jiang Liu¹ 

[1] School of Science, Xi'an Jiaotong University, 710049 Xi'an, P. R. China; E-mail:

关键词: Copper(II) sulfamate;    Biginelli reaction;    Dihydropyrimidinones.;   

DOI  :  10.3390/molecules14020763

来源: mdpi

【 摘 要 】

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.