Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydro-pyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

Molecules

Deyanira Angeles-Beltrán²  Leticia Lomas-Romero¹  Victor H. Lara-Corona¹  Eduardo González-Zamora¹ 

[1] Departamento de Química, UAM, Av. San Pablo No 180. C. P. 02200, México D. F., México; E-mail addresses: D. Angeles-Beltrán:;Departamento de Ciencias Básicas

关键词: Biginelli reaction;    Hantzsch reaction;    multicomponent reactions;    1;    4-dihydropyridines;    dihydropyrimidinones;    solventless reactions.;   

DOI  :  10.3390/11100731

来源: mdpi

【 摘 要 】

The catalytic ability of ZrO₂/SO₄^2- to promote solventless three-component condensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethyl acetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the same reactants but different temperature conditions. The sulfated zirconia catalyst can be recovered and recycled in subsequent reactions with a gradual decrease of activity.

【 授权许可】

Unknown   
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