Recent progress in the synthesis of thiazolo[3,2-a]pyrimidine compounds

2nd International Conference on New Material and Chemical Industry

材料科学;化学工业

Wu, F.Y.^1 ; Luo, Y.^1 ; Hu, C.B.^1

School of Materials and Chemical Engineering, Chongqing University of Arts and Sciences, Chongqing

402160, China^1

关键词: 2-aminothiazoles;    Aromatic aldehyde;    Biginelli reaction;    Multicomponent reactions (MCRs);    Pictet-Spengler reactions;    Recent progress;    Synthetic routes;    Unsaturated ketones;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/292/1/012038/pdf
DOI  :  10.1088/1757-899X/292/1/012038

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

In this paper, the progress in the synthesis of thiazole[3,2-a]pyrimidine compounds in the field of medicine and pesticide were reviewed. The main synthetic routes include: (i) synthesis of thiazolo[3,2-a]pyrimidines, spiro thiazolo[3,2-a]pyrimidines and pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines by multicomponent reactions (MCRs). (ii) synthesis of thiazolo[3,2-a]pyrimidines by condensation of pyrimidine-2-thiones, which were obtained by Biginelli reaction between aromatic aldehydes and thiourea, with substituted 2-bromo-1-phenylethanone or chloroacetic acid. (iii) synthesis of pyridothieno-fused thiazolo[3,2-a]pyrimidinones via Pictet-Spengler reaction. (iv) synthesis of pyrido[4,3-d]thiazolo[3,2-a]pyrimidine by reacting 2-aminothiazole with the α, β-unsaturated ketones.