Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Marine Drugs

Lee Goren Zur²  Ashgan Bishara²  Maurice Aknin¹  Drorit Neumann³  Nathalie Ben-Califa³ 

[1] Laboratorie de Chimie des Substances Naturelles et des Aliments, Faculté des Sciences et Techniques, Université de la Réunion, 15 Avenue Rene Cassin, BP 7151, Saint Denis 97715, Cedex 9, France; E-Mail:;School of Chemistry, Tel Aviv University, Ramat Aviv 69978, Israel; E-Mails:;Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel; E-Mails:

关键词: salarins;    tulearins;    Fascaplysinopsis sp.;    sponge;    nitrogenous macrolide;    leukemia cells;   

DOI  :  10.3390/md11114487

来源: mdpi

【 摘 要 】

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.