Viruses | |
Structural and Functional Comparisons of Retroviral Envelope Protein |
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Jonathan D. Steckbeck1  Anne-Sophie Kuhlmann1  | |
[1] Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; E-Mails: | |
关键词:
retroviruses;
HIV;
MuLV;
JSRV;
cytoplasmic domain;
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DOI : 10.3390/v6010284 | |
来源: mdpi | |
【 摘 要 】
Retroviruses are a family of viruses that cause a broad range of pathologies in animals and humans, from the apparently harmless, long-term genomic insertion of endogenous retroviruses, to tumors induced by the oncogenic retroviruses and acquired immunodeficiency syndrome (AIDS) resulting from human immunodeficiency virus infection. Disease can be the result of diverse mechanisms, including tumorigenesis induced by viral oncogenes or immune destruction, leading to the gradual loss of CD4 T-cells. Of the virally encoded proteins common to all retroviruses, the envelope (Env) displays perhaps the most diverse functionality. Env is primarily responsible for binding the cellular receptor and for effecting the fusion process, with these functions mediated by protein domains localized to the exterior of the virus. The remaining
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190029996ZK.pdf | 363KB | download |