Viruses | |
HIV-1 Integrase-DNA Recognition Mechanisms | |
Jacques J. Kessl1  Christopher J. McKee1  Jocelyn O. Eidahl1  Nikolozi Shkriabai1  AriKatz1  | |
[1] >Center for Retrovirus Research and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA; E-Mails: kessl.1@osu.edu (J.J.K.); mckee.473@osu.edu (C.J.M.); eidahl.1@osu.edu (J.O.E.), shkriabai.1@osu.edu (N.S.); katz.147@osu.edu (A.K | |
关键词: HIV; retroviruses; DNA; integrase; crosslinking; footprinting; | |
DOI : 10.3390/v1030713 | |
来源: mdpi | |
【 摘 要 】
Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated
【 授权许可】
CC BY
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
【 预 览 】
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