Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta

Marine Drugs

Wen-Fei He¹  Duo-Qing Xue²  Li-Gong Yao²  Jing-Ya Li²  Jia Li² 

[1] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China; E-Mail:;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; E-Mails:

关键词: sponge;    Hyrtios erecta;    Thorectidae;    hainanerectamines;    indole;    β-carboline;    Aurora A;   

DOI  :  10.3390/md12073982

来源: mdpi

【 摘 要 】

Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2–4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC₅₀ values of 24.5, 13.6, and 18.6 μg/mL, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.