Hair Dye–DNA Interaction: Plausible Cause of Mutation

Cosmetics

Swati Maiti¹  Sudarson Sekhar Sinha²  Mukesh Singh¹ 

[1] Department of Biotechnology, Haldia Institute of Technology, HIT campus, Hatiberia, Purba Medinipur, Haldia 721657, India; E-Mail:;Department of Chemistry and Biochemistry, Jackson State University, 1400 John R. Lynch Street, Jackson, MS 39217-0510, USA; E-Mail:

关键词: DNA damage;    DNA interaction;    hair dye;    spectroscopic studies;   

DOI  :  10.3390/cosmetics2040313

来源: mdpi

【 摘 要 】

Hair dye is one of the most popular cosmetic products which are used more widely and frequently to improve an individual’s appearance. Although the genotoxic effects of dye ingredients are widely reported, hair dye in its usable form is not reported extensively. In this contribution, we report the possible mode of interaction of hair dye with DNA which leads to genotoxicity. The effect of dye DNA interaction was studied on the most popular and globally used hair dye with Calf Thymus DNA and plasmid DNA. This interaction of dye DNA was studied by spectroscopic analyses and gel electrophoresis. The result had shown positive interaction of dye with DNA. Gel electrophoresis study confirms the binding of dye with DNA which results in linearization and fragmentation of the plasmid DNA. Dye–DNA interaction causes fragmentation and oxidation of DNA in absence of any catalyst, implies high toxicity of commercial hair dyes. Thus, it can be deduced from the present studies that hair dye in its usable form may lead to its penetration through skin affecting genomic DNA possesses genotoxic property and can be treated as one of the most common mutagen.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.