期刊论文详细信息
International Journal of Clinical and Experimental Medicine
Alterations in prothrombin time and activated partial thromboplastin time in patients with acute myocardial infarction
Abdullah S Alhomida1  Adnan A Khan1  Haseeb A Khan1  Mohammad S Ola1  Samia H Sobki1  Tamader Y Al Rammah1 
关键词: Acute myocardial infarction;    PT;    aPTT;    biomarker;   
DOI  :  
学科分类:医学(综合)
来源: e-Century Publishing Corporation
PDF
【 摘 要 】

Prothrombin time (PT) and activated partial thromboplastin time (aPTT) respectively measures the extrinsic and intrinsic pathways of coagulation and are used to determine the bleeding or clotting tendency of blood. We compared PT and aPTT levels in acute myocardial infarction (AMI) patients and normal subjects. There were significant increases in PT levels in patients with STEMI (15.98 ± 0.96 s), NSTEMI (16.03 ± 0.97 s) and chest pain (15.02 ± 0.54 s) as compared to control group (8.86 ± 0.08 s). The level of aPTT in control subjects was 31.35 ± 0.48 s. Patients with STEMI (40.79 ± 1.83 s), NSTEMI (41.33 ± 2.06) and chest pain (37.84 ± 1.66 s) showed significantly higher levels of aPTT. There was a significant correlation between PT and aPTT levels. Both PT and aPTT were significantly correlated with age however there was no correlation between these coagulation markers and gender or body mass index. In conclusion, both PT and aPTT are significantly increased in AMI patients on anticoagulation therapy. The elevations in PT values were more than 2.5-fold greater than aPTT suggesting a high potential of PT for predicting blood clotting tendency in patients receiving anticoagulation therapy.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201912140863585ZK.pdf 426KB PDF download
  文献评价指标  
  下载次数:4次 浏览次数:15次